Drug interactions
Lasmiditan + Tacrolimus
Severity: Moderate
Lasmiditan and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may increase exposure to P-gp substrates such as tacrolimus. Because tacrolimus has a narrow therapeutic index, even a modest increase could lead to toxicity.
What this interaction means in plain words
Lasmiditan and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Inhibition of intestinal P-glycoprotein efflux, increasing tacrolimus absorption.
What to do
Avoid lasmiditan where an alternative migraine therapy is suitable. If used, monitor tacrolimus trough levels and renal function around the time of dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Tacrolimus?
MediHelp rates the interaction as moderate. Lasmiditan and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and may increase exposure to P-gp substrates such as tacrolimus. Because tacrolimus has a narrow therapeutic index, even a modest increase could lead to toxicity.
How serious is the interaction between Lasmiditan and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid lasmiditan where an alternative migraine therapy is suitable. If used, monitor tacrolimus trough levels and renal function around the time of dosing.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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