Drug interactions
Lasmiditan + Tapentadol
Severity: Moderate
Lasmiditan and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness, somnolence and other CNS effects. Combined with an opioid such as tapentadol, sedation and impaired psychomotor function may be greater, although formal studies are lacking.
What this interaction means in plain words
Lasmiditan and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; lasmiditan acts as a 5-HT1F agonist with sedating properties.
What to do
Advise patients not to drive for at least 8 hours after lasmiditan and to watch for excessive drowsiness. Consider lower doses of the opioid if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Tapentadol?
MediHelp rates the interaction as moderate. Lasmiditan and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness, somnolence and other CNS effects. Combined with an opioid such as tapentadol, sedation and impaired psychomotor function may be greater, although formal studies are lacking.
How serious is the interaction between Lasmiditan and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive for at least 8 hours after lasmiditan and to watch for excessive drowsiness. Consider lower doses of the opioid if sedation is troublesome.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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