Drug interactions
Ledipasvir-sofosbuvir + Momelotinib
Severity: Minor
Ledipasvir-sofosbuvir and Momelotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP and may increase exposure to ledipasvir and sofosbuvir, which are BCRP substrates. The expected clinical effect is modest.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Momelotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ledipasvir-sofosbuvir belongs to Anti Virals; Momelotinib belongs to Oncology.
Why it happens
Inhibition of intestinal BCRP by momelotinib may increase absorption of the antivirals.
What to do
No empiric adjustment is needed; monitor for adverse effects of the antiviral regimen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Momelotinib?
MediHelp rates the interaction as minor. Ledipasvir-sofosbuvir and Momelotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Momelotinib inhibits BCRP and may increase exposure to ledipasvir and sofosbuvir, which are BCRP substrates. The expected clinical effect is modest.
How serious is the interaction between Ledipasvir-sofosbuvir and Momelotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed; monitor for adverse effects of the antiviral regimen.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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