Drug interactions
Ledipasvir-sofosbuvir + Sodium zirconium cyclosilicate
Severity: Moderate
Ledipasvir-sofosbuvir and Sodium zirconium cyclosilicate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can raise gastric pH, and ledipasvir absorption falls as pH rises. Reduced antiviral exposure may compromise the cure rate.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ledipasvir-sofosbuvir belongs to Anti Virals; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Higher gastric pH reduces ledipasvir solubility and absorption.
What to do
Take ledipasvir-sofosbuvir at least 2 hours before or after sodium zirconium cyclosilicate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as moderate. Ledipasvir-sofosbuvir and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium zirconium cyclosilicate can raise gastric pH, and ledipasvir absorption falls as pH rises. Reduced antiviral exposure may compromise the cure rate.
How serious is the interaction between Ledipasvir-sofosbuvir and Sodium zirconium cyclosilicate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take ledipasvir-sofosbuvir at least 2 hours before or after sodium zirconium cyclosilicate.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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