Drug interactions
Ledipasvir-sofosbuvir + Tucatinib
Severity: Minor
Ledipasvir-sofosbuvir and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-gp and may increase ledipasvir and sofosbuvir exposure. The antivirals are generally well tolerated, so the effect is probably limited.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ledipasvir-sofosbuvir belongs to Anti Virals; Tucatinib belongs to Oncology.
Why it happens
P-gp inhibition by tucatinib reduces intestinal efflux of ledipasvir and sofosbuvir.
What to do
No dose change is required; monitor for antiviral adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Tucatinib?
MediHelp rates the interaction as minor. Ledipasvir-sofosbuvir and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits P-gp and may increase ledipasvir and sofosbuvir exposure. The antivirals are generally well tolerated, so the effect is probably limited.
How serious is the interaction between Ledipasvir-sofosbuvir and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor for antiviral adverse effects.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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