Drug interactions
Lefamulin + Leuprolide
Severity: Moderate
Lefamulin and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide can lengthen the QT interval, and lefamulin also prolongs QTc. Used together, the additive effect may raise the risk of torsades de pointes, especially in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Lefamulin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Leuprolide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation through different mechanisms (hormonal effect on cardiac repolarization and ion channel effects of lefamulin).
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG after starting lefamulin, or choose a non-QT-prolonging antibiotic if the patient has other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Leuprolide?
MediHelp rates the interaction as moderate. Lefamulin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with leuprolide can lengthen the QT interval, and lefamulin also prolongs QTc. Used together, the additive effect may raise the risk of torsades de pointes, especially in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Lefamulin and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG after starting lefamulin, or choose a non-QT-prolonging antibiotic if the patient has other risk factors.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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