Drug interactions
Lefamulin + Propofol
Severity: Moderate
Lefamulin and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin prolongs the QT interval and propofol has been associated with QT prolongation and arrhythmias in some settings. Used together, particularly with electrolyte disturbances or other QT-prolonging drugs, they may raise the risk of torsades de pointes.
What this interaction means in plain words
Lefamulin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Propofol belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization causing QT interval prolongation.
What to do
Check ECG and correct potassium and magnesium before and during combined use, especially with intravenous lefamulin. Avoid adding other QT-prolonging drugs during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lefamulin and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Propofol
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Propofol?
MediHelp rates the interaction as moderate. Lefamulin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin prolongs the QT interval and propofol has been associated with QT prolongation and arrhythmias in some settings. Used together, particularly with electrolyte disturbances or other QT-prolonging drugs, they may raise the risk of torsades de pointes.
How serious is the interaction between Lefamulin and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during combined use, especially with intravenous lefamulin. Avoid adding other QT-prolonging drugs during anesthesia.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
