Drug interactions
Leflunomide + Nateglinide
Severity: Moderate
Leflunomide and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide is metabolized mainly by CYP2C9, which teriflunomide inhibits. Higher nateglinide exposure may increase the risk of hypoglycemia.
What this interaction means in plain words
Leflunomide and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leflunomide belongs to Musculoskeletal; Nateglinide belongs to Endocrine.
Why it happens
Teriflunomide inhibits CYP2C9, reducing nateglinide clearance.
What to do
Monitor blood glucose when leflunomide is started. Reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Leflunomide with Nateglinide?
MediHelp rates the interaction as moderate. Leflunomide and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide is metabolized mainly by CYP2C9, which teriflunomide inhibits. Higher nateglinide exposure may increase the risk of hypoglycemia.
How serious is the interaction between Leflunomide and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when leflunomide is started. Reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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