Drug interactions
Leflunomide + Trastuzumab
Severity: Moderate
Leflunomide and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide can cause bone marrow suppression and immunosuppression, and trastuzumab increases the rate of neutropenia when combined with chemotherapy. Used together, the risk of cytopenias and infection may be higher.
What this interaction means in plain words
Leflunomide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leflunomide belongs to Musculoskeletal; Trastuzumab belongs to Oncology.
Why it happens
Additive hematologic toxicity and immunosuppression from two agents with different mechanisms.
What to do
Check complete blood counts regularly and evaluate promptly for fever or infection. Reduce or interrupt leflunomide if significant cytopenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Leflunomide with Trastuzumab?
MediHelp rates the interaction as moderate. Leflunomide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leflunomide can cause bone marrow suppression and immunosuppression, and trastuzumab increases the rate of neutropenia when combined with chemotherapy. Used together, the risk of cytopenias and infection may be higher.
How serious is the interaction between Leflunomide and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts regularly and evaluate promptly for fever or infection. Reduce or interrupt leflunomide if significant cytopenia develops.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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