Drug interactions
Lemborexant + Nevirapine
Severity: Moderate
Lemborexant and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is predominantly a CYP3A4 inducer, so lemborexant exposure would more likely fall than rise. Lemborexant labeling advises avoiding concurrent use with moderate or strong CYP3A inducers, as efficacy may be lost.
What this interaction means in plain words
Lemborexant and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, which may increase lemborexant metabolism.
What to do
Monitor for reduced hypnotic effect. Consider an alternative insomnia agent if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Nevirapine?
MediHelp rates the interaction as moderate. Lemborexant and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine is predominantly a CYP3A4 inducer, so lemborexant exposure would more likely fall than rise. Lemborexant labeling advises avoiding concurrent use with moderate or strong CYP3A inducers, as efficacy may be lost.
How serious is the interaction between Lemborexant and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic effect. Consider an alternative insomnia agent if efficacy is lost.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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