Drug interactions
Lemborexant + Oxycodone
Severity: Moderate
Lemborexant and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a sedative-hypnotic and adds to opioid CNS depression. This may cause additive somnolence and impaired next-day psychomotor performance.
What this interaction means in plain words
Lemborexant and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from orexin receptor antagonism and opioid agonism.
What to do
Use the lowest effective doses and counsel about impaired driving and alertness. Reduce the dose of either drug if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Oxycodone?
MediHelp rates the interaction as moderate. Lemborexant and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is a sedative-hypnotic and adds to opioid CNS depression. This may cause additive somnolence and impaired next-day psychomotor performance.
How serious is the interaction between Lemborexant and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel about impaired driving and alertness. Reduce the dose of either drug if excessive sedation occurs.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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