Drug interactions
Lemborexant + Palbociclib
Severity: Moderate
Lemborexant and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib may increase lemborexant exposure through weak CYP3A4 inhibition. This can lead to greater next-day somnolence and impaired psychomotor performance.
What this interaction means in plain words
Lemborexant and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Palbociclib belongs to Oncology.
Why it happens
Palbociclib inhibits CYP3A4, reducing the metabolism of lemborexant.
What to do
Limit lemborexant to the lower labeled dose (5 mg nightly) with weak CYP3A4 inhibitors and counsel patients about daytime drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Palbociclib?
MediHelp rates the interaction as moderate. Lemborexant and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib may increase lemborexant exposure through weak CYP3A4 inhibition. This can lead to greater next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Lemborexant and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the lower labeled dose (5 mg nightly) with weak CYP3A4 inhibitors and counsel patients about daytime drowsiness.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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