Drug interactions
Lemborexant + Ranolazine
Severity: Moderate
Lemborexant and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak CYP3A4 inhibitor and may raise lemborexant exposure. This can increase next-day somnolence and impaired alertness.
What this interaction means in plain words
Lemborexant and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine weakly inhibits CYP3A4, which metabolises lemborexant.
What to do
Limit lemborexant to the lower recommended nightly dose with weak CYP3A4 inhibitors. Counsel the patient about morning drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Ranolazine?
MediHelp rates the interaction as moderate. Lemborexant and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine is a weak CYP3A4 inhibitor and may raise lemborexant exposure. This can increase next-day somnolence and impaired alertness.
How serious is the interaction between Lemborexant and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the lower recommended nightly dose with weak CYP3A4 inhibitors. Counsel the patient about morning drowsiness and driving.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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