Drug interactions
Lemborexant + Trazodone
Severity: Moderate
Lemborexant and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Weak CYP3A4 inhibition by trazodone may raise lemborexant levels, increasing somnolence and next-day impairment. Both drugs are also sedating.
What this interaction means in plain words
Lemborexant and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces lemborexant clearance, plus additive CNS depression.
What to do
Follow lemborexant labeling for dose limits with weak CYP3A4 inhibitors and monitor for daytime sedation. Counsel patients on driving and alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Trazodone?
MediHelp rates the interaction as moderate. Lemborexant and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Weak CYP3A4 inhibition by trazodone may raise lemborexant levels, increasing somnolence and next-day impairment. Both drugs are also sedating.
How serious is the interaction between Lemborexant and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow lemborexant labeling for dose limits with weak CYP3A4 inhibitors and monitor for daytime sedation. Counsel patients on driving and alertness.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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