Drug interactions
Lemborexant + Zileuton
Severity: Moderate
Lemborexant and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton may increase lemborexant concentrations by inhibiting CYP3A4. Higher exposure can lead to more next-day somnolence and impaired alertness.
What this interaction means in plain words
Lemborexant and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Zileuton belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zileuton reduces lemborexant clearance.
What to do
Limit the lemborexant nightly dose to the reduced maximum recommended in its labeling for weak CYP3A4 inhibitors. Counsel the patient about next-day drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Zileuton?
MediHelp rates the interaction as moderate. Lemborexant and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zileuton may increase lemborexant concentrations by inhibiting CYP3A4. Higher exposure can lead to more next-day somnolence and impaired alertness.
How serious is the interaction between Lemborexant and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lemborexant nightly dose to the reduced maximum recommended in its labeling for weak CYP3A4 inhibitors. Counsel the patient about next-day drowsiness and driving.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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