Drug interactions
Lenacapavir + Linagliptin
Severity: Minor
Lenacapavir and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and also inhibits P-gp, so linagliptin exposure may rise somewhat. Given linagliptin's wide therapeutic margin, a significant clinical effect is unlikely.
What this interaction means in plain words
Lenacapavir and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenacapavir belongs to Anti Virals; Linagliptin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by lenacapavir may decrease linagliptin clearance.
What to do
No dose adjustment is needed; monitor glucose and watch for hypoglycemia if combined with other antidiabetics.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Linagliptin?
MediHelp rates the interaction as minor. Lenacapavir and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor and also inhibits P-gp, so linagliptin exposure may rise somewhat. Given linagliptin's wide therapeutic margin, a significant clinical effect is unlikely.
How serious is the interaction between Lenacapavir and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor glucose and watch for hypoglycemia if combined with other antidiabetics.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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