Drug interactions
Lenacapavir + Methylprednisolone
Severity: Moderate
Lenacapavir and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise methylprednisolone exposure, increasing the risk of corticosteroid adverse effects such as adrenal suppression and hyperglycemia. The effect can persist for months after subcutaneous dosing.
What this interaction means in plain words
Lenacapavir and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Methylprednisolone belongs to Endocrine.
Why it happens
Lenacapavir inhibits CYP3A4, reducing methylprednisolone clearance.
What to do
Monitor for corticosteroid toxicity and consider reducing the methylprednisolone dose, particularly with prolonged use. Keep the long duration of lenacapavir effect in mind.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Methylprednisolone?
MediHelp rates the interaction as moderate. Lenacapavir and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may raise methylprednisolone exposure, increasing the risk of corticosteroid adverse effects such as adrenal suppression and hyperglycemia. The effect can persist for months after subcutaneous dosing.
How serious is the interaction between Lenacapavir and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid toxicity and consider reducing the methylprednisolone dose, particularly with prolonged use. Keep the long duration of lenacapavir effect in mind.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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