Drug interactions
Lenacapavir + Mirtazapine
Severity: Minor
Lenacapavir and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor with a long persistence after subcutaneous dosing. Mirtazapine is partly metabolized by CYP3A4, so exposure may rise modestly, increasing sedation or other adverse effects.
What this interaction means in plain words
Lenacapavir and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenacapavir belongs to Anti Virals; Mirtazapine belongs to Central Nervous System.
Why it happens
Lenacapavir inhibits CYP3A4, reducing mirtazapine metabolism.
What to do
Monitor for sedation, dizziness and other adverse effects and reduce the mirtazapine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Mirtazapine?
MediHelp rates the interaction as minor. Lenacapavir and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor with a long persistence after subcutaneous dosing. Mirtazapine is partly metabolized by CYP3A4, so exposure may rise modestly, increasing sedation or other adverse effects.
How serious is the interaction between Lenacapavir and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and other adverse effects and reduce the mirtazapine dose if they occur.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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