Drug interactions
Lenacapavir + Palbociclib
Severity: Moderate
Lenacapavir and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and can increase exposure to CYP3A substrates such as palbociclib. This may raise the risk of neutropenia.
What this interaction means in plain words
Lenacapavir and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Palbociclib belongs to Oncology.
Why it happens
Lenacapavir inhibits CYP3A4, decreasing palbociclib metabolism.
What to do
Monitor complete blood counts closely and reduce the palbociclib dose if neutropenia or other toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Palbociclib?
MediHelp rates the interaction as moderate. Lenacapavir and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and can increase exposure to CYP3A substrates such as palbociclib. This may raise the risk of neutropenia.
How serious is the interaction between Lenacapavir and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and reduce the palbociclib dose if neutropenia or other toxicity occurs.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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