Drug interactions
Lenacapavir + Ruxolitinib
Severity: Moderate
Lenacapavir and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir inhibits CYP3A4 and has a very long half-life after subcutaneous dosing, so the inhibition can persist for months. Ruxolitinib exposure may increase, raising the risk of thrombocytopenia, anemia and neutropenia.
What this interaction means in plain words
Lenacapavir and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Ruxolitinib belongs to Oncology.
Why it happens
Lenacapavir is a moderate CYP3A4 inhibitor that decreases ruxolitinib clearance.
What to do
Monitor complete blood counts closely and reduce the ruxolitinib dose per labeling for CYP3A4 inhibitors if cytopenias or excess effect occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Ruxolitinib?
MediHelp rates the interaction as moderate. Lenacapavir and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir inhibits CYP3A4 and has a very long half-life after subcutaneous dosing, so the inhibition can persist for months. Ruxolitinib exposure may increase, raising the risk of thrombocytopenia, anemia and neutropenia.
How serious is the interaction between Lenacapavir and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and reduce the ruxolitinib dose per labeling for CYP3A4 inhibitors if cytopenias or excess effect occur.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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