Drug interactions
Lenacapavir + Trazodone
Severity: Moderate
Lenacapavir and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and can raise trazodone concentrations, with an effect that may persist for months after subcutaneous dosing. This can increase sedation, hypotension, and QT risk.
What this interaction means in plain words
Lenacapavir and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Trazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated trazodone metabolism by lenacapavir.
What to do
Start trazodone at a low dose and titrate based on response, and monitor for sedation and dizziness. Keep this in mind for several months after the last lenacapavir injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Trazodone?
MediHelp rates the interaction as moderate. Lenacapavir and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and can raise trazodone concentrations, with an effect that may persist for months after subcutaneous dosing. This can increase sedation, hypotension, and QT risk.
How serious is the interaction between Lenacapavir and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start trazodone at a low dose and titrate based on response, and monitor for sedation and dizziness. Keep this in mind for several months after the last lenacapavir injection.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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