Drug interactions
Lenacapavir + Trimipramine
Severity: Moderate
Lenacapavir and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise concentrations of CYP3A substrates such as trimipramine. Higher tricyclic levels can increase sedation, anticholinergic effects and cardiac conduction effects.
What this interaction means in plain words
Lenacapavir and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Trimipramine belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by lenacapavir reduces trimipramine metabolism.
What to do
Monitor for tricyclic toxicity and consider an ECG; lower the trimipramine dose if adverse effects emerge. Be aware that the inhibitory effect may persist for months after the last subcutaneous lenacapavir dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Trimipramine?
MediHelp rates the interaction as moderate. Lenacapavir and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may raise concentrations of CYP3A substrates such as trimipramine. Higher tricyclic levels can increase sedation, anticholinergic effects and cardiac conduction effects.
How serious is the interaction between Lenacapavir and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider an ECG; lower the trimipramine dose if adverse effects emerge. Be aware that the inhibitory effect may persist for months after the last subcutaneous lenacapavir dose.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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