Drug interactions
Lenacapavir + Vortioxetine
Severity: Minor
Lenacapavir and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may modestly raise vortioxetine levels, with effect persisting after subcutaneous dosing is stopped. The effect is likely small as CYP2D6 is the main route.
What this interaction means in plain words
Lenacapavir and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenacapavir belongs to Anti Virals; Vortioxetine belongs to Central Nervous System.
Why it happens
Lenacapavir inhibits CYP3A4, slightly reducing vortioxetine's secondary clearance.
What to do
No routine dose change is needed; monitor for increased adverse effects such as nausea, particularly in CYP2D6 poor metabolizers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Vortioxetine?
MediHelp rates the interaction as minor. Lenacapavir and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor and may modestly raise vortioxetine levels, with effect persisting after subcutaneous dosing is stopped. The effect is likely small as CYP2D6 is the main route.
How serious is the interaction between Lenacapavir and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for increased adverse effects such as nausea, particularly in CYP2D6 poor metabolizers.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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