Drug interactions
Lenalidomide + Vedolizumab
Severity: Moderate
Lenalidomide and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenalidomide is an immunomodulatory agent that can cause neutropenia and thrombocytopenia, which may add to infection risk when combined with vedolizumab. The overall interaction is mainly theoretical because vedolizumab's effect is largely gut-selective.
What this interaction means in plain words
Lenalidomide and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenalidomide belongs to Oncology; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immune effects from lenalidomide-related myelosuppression and gut-selective integrin blockade.
What to do
Monitor blood counts and watch for infection, particularly GI infections. Interrupt therapy if serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Lenalidomide
- Deferiprone + Lenalidomide Major
- Lenalidomide + Ropeginterferon alfa 2b Major
- Acalabrutinib + Lenalidomide Moderate
- Anakinra + Lenalidomide Moderate
- Cholera vaccine + Lenalidomide Moderate
- Denosumab + Lenalidomide Moderate
Frequently asked questions
Can I take Lenalidomide with Vedolizumab?
MediHelp rates the interaction as moderate. Lenalidomide and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenalidomide is an immunomodulatory agent that can cause neutropenia and thrombocytopenia, which may add to infection risk when combined with vedolizumab. The overall interaction is mainly theoretical because vedolizumab's effect is largely gut-selective.
How serious is the interaction between Lenalidomide and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection, particularly GI infections. Interrupt therapy if serious infection develops.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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