Drug interactions
Leniolisib + Melatonin
Severity: Minor
Leniolisib and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is a weak to moderate CYP1A2 inhibitor in label data, and melatonin depends on CYP1A2 for clearance. Melatonin levels and drowsiness may increase.
What this interaction means in plain words
Leniolisib and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Leniolisib belongs to Miscellaneous; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP1A2-mediated melatonin metabolism.
What to do
Start with a low melatonin dose and monitor for next-day sedation. Reduce the dose if drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Melatonin?
MediHelp rates the interaction as minor. Leniolisib and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib is a weak to moderate CYP1A2 inhibitor in label data, and melatonin depends on CYP1A2 for clearance. Melatonin levels and drowsiness may increase.
How serious is the interaction between Leniolisib and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low melatonin dose and monitor for next-day sedation. Reduce the dose if drowsiness occurs.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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