Drug interactions
Lenvatinib + Memantine-donepezil
Severity: Moderate
Lenvatinib and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib can prolong the QT interval and donepezil may add to this effect. Together they increase the risk of serious arrhythmia, especially with electrolyte disturbances.
What this interaction means in plain words
Lenvatinib and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes at baseline and periodically, correcting potassium, magnesium and calcium. Interrupt lenvatinib per labeling if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Memantine-donepezil?
MediHelp rates the interaction as moderate. Lenvatinib and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib can prolong the QT interval and donepezil may add to this effect. Together they increase the risk of serious arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Lenvatinib and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, correcting potassium, magnesium and calcium. Interrupt lenvatinib per labeling if QTc becomes markedly prolonged.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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