Drug interactions
Lenvatinib + Quinidine
Severity: Major
Lenvatinib and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both quinidine and lenvatinib can prolong the QT interval, and lenvatinib labeling advises close ECG monitoring with other QT-prolonging drugs. Combined use increases the risk of torsades de pointes, particularly with electrolyte abnormalities.
What this interaction means in plain words
Lenvatinib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lenvatinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Avoid the combination if possible. If necessary, monitor ECG and correct potassium, magnesium and calcium before and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Quinidine?
MediHelp rates the interaction as major. Lenvatinib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both quinidine and lenvatinib can prolong the QT interval, and lenvatinib labeling advises close ECG monitoring with other QT-prolonging drugs. Combined use increases the risk of torsades de pointes, particularly with electrolyte abnormalities.
How serious is the interaction between Lenvatinib and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, monitor ECG and correct potassium, magnesium and calcium before and during treatment.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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