Drug interactions
Lenvatinib + Sertraline
Severity: Moderate
Lenvatinib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib can prolong the QT interval, and sertraline adds a modest effect. The combination may increase the risk of QT-related arrhythmia, particularly with electrolyte disturbance.
What this interaction means in plain words
Lenvatinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Monitor the ECG and keep potassium, magnesium and calcium within normal ranges. Interrupt lenvatinib or change the antidepressant if the QTc is markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Sertraline?
MediHelp rates the interaction as moderate. Lenvatinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib can prolong the QT interval, and sertraline adds a modest effect. The combination may increase the risk of QT-related arrhythmia, particularly with electrolyte disturbance.
How serious is the interaction between Lenvatinib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and keep potassium, magnesium and calcium within normal ranges. Interrupt lenvatinib or change the antidepressant if the QTc is markedly prolonged.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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