Drug interactions
Leriglitazone + Sulphasalazine
Severity: Moderate
Leriglitazone and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leriglitazone may increase sulfasalazine exposure through BCRP inhibition. This could increase adverse effects such as gastrointestinal upset, rash and blood dyscrasias.
What this interaction means in plain words
Leriglitazone and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leriglitazone belongs to Central Nervous System; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of BCRP efflux transporter increases sulfasalazine absorption and reduces elimination.
What to do
Monitor for sulfasalazine adverse effects and blood counts, and reduce the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leriglitazone
- Gemfibrozil + Leriglitazone Major
- Carbamazepine + Leriglitazone Moderate
- Clarithromycin + Leriglitazone Moderate
- Gliclazide + Leriglitazone Moderate
- Itraconazole + Leriglitazone Moderate
- Ketoconazole + Leriglitazone Moderate
Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Frequently asked questions
Can I take Leriglitazone with Sulphasalazine?
MediHelp rates the interaction as moderate. Leriglitazone and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leriglitazone may increase sulfasalazine exposure through BCRP inhibition. This could increase adverse effects such as gastrointestinal upset, rash and blood dyscrasias.
How serious is the interaction between Leriglitazone and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects and blood counts, and reduce the dose if needed.
What other medicines interact with Leriglitazone?
MediHelp also lists interactions of Leriglitazone with, for example, Gemfibrozil, Carbamazepine, Clarithromycin. The full list is on the Leriglitazone page.
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