Drug interactions
Lesinurad + Levoketoconazole
Severity: Moderate
Lesinurad and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole may increase lesinurad exposure, which could raise the risk of renal adverse effects. Lesinurad exposure rises with CYP2C9 inhibition, but the effect with ketoconazole-type inhibitors is modest.
What this interaction means in plain words
Lesinurad and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lesinurad belongs to Genitourinary; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP2C9, reducing lesinurad metabolism.
What to do
Monitor serum creatinine and renal function closely. Reduce or stop lesinurad if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Lesinurad with Levoketoconazole?
MediHelp rates the interaction as moderate. Lesinurad and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole may increase lesinurad exposure, which could raise the risk of renal adverse effects. Lesinurad exposure rises with CYP2C9 inhibition, but the effect with ketoconazole-type inhibitors is modest.
How serious is the interaction between Lesinurad and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and renal function closely. Reduce or stop lesinurad if renal function declines.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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