Drug interactions
Letermovir + Pravastatin
Severity: Moderate
Letermovir and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir increases pravastatin exposure, raising the risk of myopathy and rhabdomyolysis. The effect is greater when cyclosporine is also given.
What this interaction means in plain words
Letermovir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Pravastatin belongs to Cardiovascular.
Why it happens
Letermovir inhibits hepatic uptake transporters OATP1B1/3, reducing hepatic uptake of pravastatin.
What to do
Monitor for muscle toxicity and reduce the pravastatin dose if needed. If cyclosporine is also given, limit pravastatin to 20 mg daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Pravastatin?
MediHelp rates the interaction as moderate. Letermovir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir increases pravastatin exposure, raising the risk of myopathy and rhabdomyolysis. The effect is greater when cyclosporine is also given.
How serious is the interaction between Letermovir and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle toxicity and reduce the pravastatin dose if needed. If cyclosporine is also given, limit pravastatin to 20 mg daily.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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