Drug interactions
Letermovir + Rimegepant
Severity: Moderate
Letermovir and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may increase rimegepant exposure. Higher exposure may increase the likelihood of adverse effects.
What this interaction means in plain words
Letermovir and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of rimegepant by letermovir.
What to do
For acute treatment, avoid repeating rimegepant within 48 hours. No change is needed for preventive dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Rimegepant?
MediHelp rates the interaction as moderate. Letermovir and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and may increase rimegepant exposure. Higher exposure may increase the likelihood of adverse effects.
How serious is the interaction between Letermovir and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For acute treatment, avoid repeating rimegepant within 48 hours. No change is needed for preventive dosing.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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