Drug interactions
Letermovir + Rosiglitazone
Severity: Moderate
Letermovir and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP2C8 and may increase rosiglitazone exposure, potentially intensifying glucose lowering and fluid retention. The magnitude has not been well characterized for rosiglitazone specifically.
What this interaction means in plain words
Letermovir and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Rosiglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP2C8-mediated rosiglitazone metabolism by letermovir.
What to do
Monitor blood glucose and signs of edema during coadministration. Reduce rosiglitazone dose if hypoglycemia or fluid retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Rosiglitazone?
MediHelp rates the interaction as moderate. Letermovir and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP2C8 and may increase rosiglitazone exposure, potentially intensifying glucose lowering and fluid retention. The magnitude has not been well characterized for rosiglitazone specifically.
How serious is the interaction between Letermovir and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and signs of edema during coadministration. Reduce rosiglitazone dose if hypoglycemia or fluid retention develops.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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