Drug interactions
Letermovir + Rosuvastatin
Severity: Major
Letermovir and Rosuvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir increases rosuvastatin exposure, raising the risk of myopathy and rhabdomyolysis. The risk is greater when cyclosporine is also given.
What this interaction means in plain words
Letermovir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Letermovir belongs to Anti Virals; Rosuvastatin belongs to Cardiovascular.
Why it happens
Letermovir inhibits OATP1B1/1B3 hepatic uptake of rosuvastatin, increasing plasma concentrations; CYP3A4 is not a major rosuvastatin pathway.
What to do
Avoid combining with letermovir if cyclosporine is also used, or limit rosuvastatin to the labeled maximum dose. Monitor closely for muscle pain, weakness and elevated creatine kinase.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rosuvastatin
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Rosuvastatin?
MediHelp rates the interaction as major. Letermovir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir increases rosuvastatin exposure, raising the risk of myopathy and rhabdomyolysis. The risk is greater when cyclosporine is also given.
How serious is the interaction between Letermovir and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with letermovir if cyclosporine is also used, or limit rosuvastatin to the labeled maximum dose. Monitor closely for muscle pain, weakness and elevated creatine kinase.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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