Drug interactions
Letermovir + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Letermovir and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxilaprevir and velpatasvir inhibit OATP1B1/3, which may increase letermovir concentrations. Letermovir may also affect hepatic transporters and CYP enzymes, so effects may go both ways. Increased letermovir exposure may add to GI and other adverse effects.
What this interaction means in plain words
Letermovir and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Voxilaprevir inhibits hepatic OATP1B1/3 uptake of letermovir, raising its plasma concentrations.
What to do
Monitor for letermovir adverse effects such as nausea, diarrhea and peripheral edema. No empirical dose change is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Letermovir and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxilaprevir and velpatasvir inhibit OATP1B1/3, which may increase letermovir concentrations. Letermovir may also affect hepatic transporters and CYP enzymes, so effects may go both ways. Increased letermovir exposure may add to GI and other adverse effects.
How serious is the interaction between Letermovir and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for letermovir adverse effects such as nausea, diarrhea and peripheral edema. No empirical dose change is needed.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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