Drug interactions
Letermovir + Solifenacin
Severity: Moderate
Letermovir and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A moderately and can raise exposure to solifenacin. Anticholinergic effects and QT-related risk may increase.
What this interaction means in plain words
Letermovir and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Solifenacin belongs to Genitourinary.
Why it happens
Letermovir inhibits CYP3A4, reducing solifenacin metabolism.
What to do
Monitor for anticholinergic toxicity and consider reducing the solifenacin dose, especially with other QT-prolonging drugs or renal or hepatic impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Solifenacin?
MediHelp rates the interaction as moderate. Letermovir and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A moderately and can raise exposure to solifenacin. Anticholinergic effects and QT-related risk may increase.
How serious is the interaction between Letermovir and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider reducing the solifenacin dose, especially with other QT-prolonging drugs or renal or hepatic impairment.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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