Drug interactions
Leuprolide + Metformin-repaglinide
Severity: Moderate
Leuprolide and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with GnRH agonists such as leuprolide can reduce insulin sensitivity and worsen glycemic control. Patients with diabetes may need intensification of therapy.
What this interaction means in plain words
Leuprolide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
GnRH agonist-induced hypogonadism increases insulin resistance and adiposity, opposing antidiabetic effects.
What to do
Monitor blood glucose and HbA1c during leuprolide therapy and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Leuprolide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with GnRH agonists such as leuprolide can reduce insulin sensitivity and worsen glycemic control. Patients with diabetes may need intensification of therapy.
How serious is the interaction between Leuprolide and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during leuprolide therapy and adjust the antidiabetic regimen as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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