Drug interactions
Leuprolide + Pazopanib
Severity: Moderate
Leuprolide and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is labeled for QT prolongation and torsades de pointes, and androgen deprivation with leuprolide may add to this. The combined risk is higher in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Leuprolide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation through pazopanib's effect on cardiac repolarization and testosterone suppression by leuprolide.
What to do
Obtain a baseline ECG and monitor it periodically, and maintain normal potassium and magnesium. Interrupt or reduce pazopanib if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Leuprolide with Pazopanib?
MediHelp rates the interaction as moderate. Leuprolide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is labeled for QT prolongation and torsades de pointes, and androgen deprivation with leuprolide may add to this. The combined risk is higher in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Leuprolide and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and maintain normal potassium and magnesium. Interrupt or reduce pazopanib if QTc becomes significantly prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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