Drug interactions
Leuprolide + Pitolisant
Severity: Moderate
Leuprolide and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can prolong the QT interval and leuprolide may also lengthen QTc through androgen deprivation. Combined use may add to the risk of arrhythmia, particularly with other risk factors.
What this interaction means in plain words
Leuprolide and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Pitolisant belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation via separate mechanisms.
What to do
Check a baseline ECG and electrolytes and repeat after initiation. Avoid the pair in patients with congenital long QT, bradycardia or hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Leuprolide with Pitolisant?
MediHelp rates the interaction as moderate. Leuprolide and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant can prolong the QT interval and leuprolide may also lengthen QTc through androgen deprivation. Combined use may add to the risk of arrhythmia, particularly with other risk factors.
How serious is the interaction between Leuprolide and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat after initiation. Avoid the pair in patients with congenital long QT, bradycardia or hypokalemia.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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