Drug interactions
Leuprolide + Sorafenib
Severity: Moderate
Leuprolide and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and androgen deprivation with leuprolide may also lengthen it. Together they may increase the risk of ventricular arrhythmia, particularly with electrolyte abnormalities.
What this interaction means in plain words
Leuprolide and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation from sorafenib and from testosterone suppression by leuprolide.
What to do
Monitor ECG and electrolytes at baseline and periodically, and correct potassium and magnesium deficits. Avoid further QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Leuprolide with Sorafenib?
MediHelp rates the interaction as moderate. Leuprolide and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, and androgen deprivation with leuprolide may also lengthen it. Together they may increase the risk of ventricular arrhythmia, particularly with electrolyte abnormalities.
How serious is the interaction between Leuprolide and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, and correct potassium and magnesium deficits. Avoid further QT-prolonging drugs where possible.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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