Drug interactions
Leuprolide + Sunitinib
Severity: Moderate
Leuprolide and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib is labeled for QT prolongation and torsades de pointes, and androgen deprivation with leuprolide may add to the effect. The risk is greater in patients with heart disease or low electrolytes.
What this interaction means in plain words
Leuprolide and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Sunitinib belongs to Oncology.
Why it happens
Additive QT prolongation from sunitinib and leuprolide-induced androgen deprivation.
What to do
Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium. Reduce the sunitinib dose or interrupt it if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Leuprolide with Sunitinib?
MediHelp rates the interaction as moderate. Leuprolide and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib is labeled for QT prolongation and torsades de pointes, and androgen deprivation with leuprolide may add to the effect. The risk is greater in patients with heart disease or low electrolytes.
How serious is the interaction between Leuprolide and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium. Reduce the sunitinib dose or interrupt it if QTc becomes markedly prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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