Drug interactions
Leuprolide + Telavancin
Severity: Moderate
Leuprolide and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide-induced androgen deprivation can prolong the QT interval, and telavancin may add to this effect. The combination may raise the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Leuprolide and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Telavancin belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation; androgen suppression alters cardiac repolarization, telavancin has a separate effect.
What to do
Check ECG and electrolytes before telavancin and repeat during treatment. Correct potassium and magnesium deficits and review other QT-prolonging medicines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Telavancin?
MediHelp rates the interaction as moderate. Leuprolide and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leuprolide-induced androgen deprivation can prolong the QT interval, and telavancin may add to this effect. The combination may raise the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Leuprolide and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before telavancin and repeat during treatment. Correct potassium and magnesium deficits and review other QT-prolonging medicines.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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