Drug interactions
Levamlodipine + Mifepristone
Severity: Moderate
Levamlodipine and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may raise levamlodipine concentrations by inhibiting CYP3A4. This can cause excessive blood pressure lowering, peripheral edema and reflex tachycardia.
What this interaction means in plain words
Levamlodipine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levamlodipine belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of levamlodipine.
What to do
Monitor blood pressure and for edema, and reduce the levamlodipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Levamlodipine with Mifepristone?
MediHelp rates the interaction as moderate. Levamlodipine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may raise levamlodipine concentrations by inhibiting CYP3A4. This can cause excessive blood pressure lowering, peripheral edema and reflex tachycardia.
How serious is the interaction between Levamlodipine and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema, and reduce the levamlodipine dose if hypotension or edema occurs.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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