Drug interactions
Levamlodipine + Simvastatin
Severity: Moderate
Levamlodipine and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levamlodipine, the active enantiomer of amlodipine, is expected to raise simvastatin exposure as amlodipine does, increasing the risk of myopathy.
What this interaction means in plain words
Levamlodipine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levamlodipine belongs to Cardiovascular; Simvastatin belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4 by the amlodipine class reduces simvastatin metabolism.
What to do
Limit simvastatin to 20 mg daily with levamlodipine, and counsel the patient to report muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Levamlodipine with Simvastatin?
MediHelp rates the interaction as moderate. Levamlodipine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levamlodipine, the active enantiomer of amlodipine, is expected to raise simvastatin exposure as amlodipine does, increasing the risk of myopathy.
How serious is the interaction between Levamlodipine and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit simvastatin to 20 mg daily with levamlodipine, and counsel the patient to report muscle pain or weakness.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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