Drug interactions
Levamlodipine + Verapamil
Severity: Moderate
Levamlodipine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and increases exposure to levamlodipine, the active enantiomer of amlodipine. This may cause hypotension, peripheral edema and dizziness. Combining two calcium channel blockers also adds pharmacodynamic effects.
What this interaction means in plain words
Levamlodipine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levamlodipine belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition reduces levamlodipine metabolism, with additive calcium channel blockade.
What to do
Monitor blood pressure and for edema, and reduce the levamlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Levamlodipine with Verapamil?
MediHelp rates the interaction as moderate. Levamlodipine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and increases exposure to levamlodipine, the active enantiomer of amlodipine. This may cause hypotension, peripheral edema and dizziness. Combining two calcium channel blockers also adds pharmacodynamic effects.
How serious is the interaction between Levamlodipine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema, and reduce the levamlodipine dose if hypotension or edema develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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