Drug interactions
Levetiracetam + Oxycodone
Severity: Moderate
Levetiracetam and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, so together they may add to sedation and psychomotor impairment. Clinically significant respiratory depression is less likely than with other sedatives but possible.
What this interaction means in plain words
Levetiracetam and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; no pharmacokinetic interaction is established.
What to do
Start oxycodone at a low dose and titrate cautiously. Advise patients about impaired driving and monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Oxycodone?
MediHelp rates the interaction as moderate. Levetiracetam and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, so together they may add to sedation and psychomotor impairment. Clinically significant respiratory depression is less likely than with other sedatives but possible.
How serious is the interaction between Levetiracetam and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start oxycodone at a low dose and titrate cautiously. Advise patients about impaired driving and monitor for excessive sedation.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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