Drug interactions
Levetiracetam + Pregabalin
Severity: Minor
Levetiracetam and Pregabalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause somnolence, dizziness and fatigue, so sedation may be greater in combination. There is no important pharmacokinetic interaction.
What this interaction means in plain words
Levetiracetam and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levetiracetam belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Warn about drowsiness and driving, especially during titration. Adjust doses if sedation is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levetiracetam and Pregabalin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pregabalin
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Pregabalin?
MediHelp rates the interaction as minor. Levetiracetam and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents can cause somnolence, dizziness and fatigue, so sedation may be greater in combination. There is no important pharmacokinetic interaction.
How serious is the interaction between Levetiracetam and Pregabalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn about drowsiness and driving, especially during titration. Adjust doses if sedation is excessive.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
