Drug interactions
Levetiracetam + Stiripentol
Severity: Moderate
Levetiracetam and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol commonly causes somnolence and levetiracetam also causes drowsiness and fatigue, so combined use can increase sedation. This is relevant because the two are sometimes used together for refractory epilepsy.
What this interaction means in plain words
Levetiracetam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for somnolence, ataxia and reduced alertness, and adjust the dose of either drug if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Stiripentol
Frequently asked questions
Can I take Levetiracetam with Stiripentol?
MediHelp rates the interaction as moderate. Levetiracetam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol commonly causes somnolence and levetiracetam also causes drowsiness and fatigue, so combined use can increase sedation. This is relevant because the two are sometimes used together for refractory epilepsy.
How serious is the interaction between Levetiracetam and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, ataxia and reduced alertness, and adjust the dose of either drug if sedation is excessive.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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