Drug interactions
Levetiracetam + Tramadol
Severity: Moderate
Levetiracetam and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may cause somnolence and dizziness, so combined use can increase sedation. Tramadol can lower seizure threshold, which may counteract anticonvulsant control in epilepsy.
What this interaction means in plain words
Levetiracetam and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with tramadol pharmacodynamically opposing anticonvulsant effect.
What to do
Monitor sedation and seizure control, and consider a non-tramadol analgesic in patients with epilepsy. Counsel on driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levetiracetam and Tramadol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Tramadol?
MediHelp rates the interaction as moderate. Levetiracetam and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may cause somnolence and dizziness, so combined use can increase sedation. Tramadol can lower seizure threshold, which may counteract anticonvulsant control in epilepsy.
How serious is the interaction between Levetiracetam and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure control, and consider a non-tramadol analgesic in patients with epilepsy. Counsel on driving and machinery.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
