Drug interactions
Levetiracetam + Vigabatrin
Severity: Minor
Levetiracetam and Vigabatrin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antiseizure drugs can cause somnolence, fatigue and dizziness, so sedation may be somewhat greater when they are combined. The combination is commonly used in epilepsy and is usually well tolerated.
What this interaction means in plain words
Levetiracetam and Vigabatrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levetiracetam belongs to Central Nervous System; Vigabatrin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no meaningful pharmacokinetic interaction is established.
What to do
Warn the patient about drowsiness and impaired alertness, especially during dose titration. Reduce the dose if sedation becomes troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Vigabatrin?
MediHelp rates the interaction as minor. Levetiracetam and Vigabatrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both antiseizure drugs can cause somnolence, fatigue and dizziness, so sedation may be somewhat greater when they are combined. The combination is commonly used in epilepsy and is usually well tolerated.
How serious is the interaction between Levetiracetam and Vigabatrin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and impaired alertness, especially during dose titration. Reduce the dose if sedation becomes troublesome.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
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